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The polypeptide GHRP-2, also known as GHRP or KP-102
Secretogogue peptide with a molecular formula
C45H55N9O6 and a molecular weight of 817.9
According to scientific research that has been conducted on various test subjects, GHRP-2 has been shown to have an ability to stimulate the pituitary gland; the pea-sized gland located at the base of the brain that is responsible for the regulation of several endocrine system related functions, such as growth, pain relief, temperature regulation, and blood pressure regulation. It is considered to be non-glycosylated. Its chemical makeup enables it to boost the natural endocrine system-related secretions amongst the test subjects. Specifically, GHRP-2’s functionality allows it to promote the release of secretions put forth by somatropic cells; the cells that are chiefly responsible for the regulation of growth within the test subjects. At the same time, the peptide contains the capacity to block the secretion of somatostatin; a peptide that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled receptors.
Additional Functionalities of GHRP – 2
Scientific studies based on test subjects have determined that GHRP – 2 also stimulates ghrelin production. Ghrelin is a self-regulating peptide consisting of 28 amino acids. It is primarily produced by the stomach, although it can also be expressed by the epsilon cells of the pancreas. Its primary function is to stimulate hunger in test subjects. GHRP-2’s ability to stimulate ghrelin production enables test subjects to have an increased desire to consume more food. Additionally, GHRP-2 has been shown to boost the functionality of the hypothalamus; the part of the brain that links the endocrine system with the nervous system. This increase in hypothalamus functionality has also been shown to aid in the increase of appetite.
Additionally, studies show that GHRP-2 contains the ability to increase levels of calcium ion influx, a process that can duplicate even further production of growth-related secretions. The peptide has also been shown to have the ability to promote level increases of IGF-1 (also known as somatomedin C); a liver-produced protein that is instrumental in the growth and repair of muscles and tissues.
All of these processes that are tied to GHRP-2 work in conjunction with each other to provide a boost in protein synthesis and ultimately, a more efficient means of achieving homeostasis.